CD14 expression in 13 human volunteers receiving non-lethal E. coli LPS injections revealed that all patients exhibited significant monocytopenia after LPS infusion, with a 52% down-regulation of CD14 expression compared to pre-LPS levels on monocytes obtained 3 h after LPS infusion (70) and that the LPS-induced significant monocytopenia is likewise supported by studies reported by Kathryn et al. (71). Here, CD14 is linked to Decreased total monocyte count.