TRPV1 and irritable bowel syndrome: For example, TRPA1 and TRPV1 are highly expressed in intestinal epithelial cells and stenotic tissue samples from patients with IBD, affect the progression of colitis and fibrosis in mice, and contribute to the development of nociceptive hypersensitivity and inflammation in the intestinal mucosa (Rizopoulos et al., 2018; Csekő et al., 2019; Inoue et al., 2019).