PIEZO1 and neoplasm: Notably, several studies have shown that the expression of Piezo1 is associated with the clinical features of cancer patients, and high levels of Piezo1 are negatively correlated with the overall survival of tumor patients, making Piezo1 a novel biomarker for the diagnosis and prognosis of various human cancers (Dombroski et al., 2021; Yu and Liao, 2021).