Xie et al. (2023) found that Piezo2 channels in TRPV1 lineage neurons are key mediators of visceral mechanosensitivity and nociception under normal conditions. Ablation of Piezo2 channels reduces visceral afferent action potential firing and visceromotor responses in both physiological states and mouse models of IBS and partial colonic obstruction. Interestingly, in GI transit, lack of Piezo2 in sensory neurons leads to delayed evacuation and diarrhea-like behavior, possibly due to failure to resorb water caused by reduced transit times (Servin-Vences et al., 2023). This evidence concerns the gene TRPV1 and irritable bowel syndrome.