Gonzalez-Pérez et al. (32) described on a regional scale different patterns of molecular reactivity dependent on climate and other factors, in which the allergens Der p 21, Der p 5 and Der p 7 also appeared as serodominant molecules, in addition to the highly prevalent IgE responses to major HDM allergens, especially in subjects with asthma and atopic dermatitis. The gene discussed is IGHE; the disease is asthma.