In this study, 6 hub genes,NKX2-1,CD8A,SFTA3,IL2RB,IDO1, andCXCL9, which are all M1 macrophage coexpressed genes, were utilized to build the immunotherapy response model.NKX2-1 can regulate lung cancer growth by targeting the MAPK pathway[33]. Here, CD8A is linked to lung cancer.