Aβ is a major component of AD-related amyloid plaques and is derived from the complex cleavage of amyloid-β protein precursor (APP), which is a type I single-pass transmembrane protein in humans consisting of 639 to 770 amino acids; it is highly expressed in the central nervous system (CNS) and plays a variety of physiological functions [77, 78]. This evidence concerns the gene APP and Alzheimer disease.