Prostate cancer is manifested as low tumor mutation burden, scarcity of tumor infiltrating CD8+ cytotoxic T cells, and infiltration of multiple immunosuppressive cell subsets in the tumor microenvironment,7, 8, 9, 10 in which case, resistance to photon radiation therapy is induced through various mechanisms,11, 12, 13 thus compromising the improvement of therapeutic efficacy. Here, CD8A is linked to Familial prostate cancer.