The second and third columns demonstrated that the number of synaptic vesicles (SVs) in per μm2 was significantly decreased in APP/PS1 rats, compared to WT and RIC intervention groups (Figure 3B‐b1; Kruskal–Wallis, p < 0.001, WT vs. APP/PS1 Z = 20.829; AD vs. RIC Z = 20.698; WT vs. RIC Z = 5.216). The gene discussed is APP; the disease is Alzheimer disease.