BRCA1 and breast cancer: Stjepanovic and coworkers [11] report that the cumulative BC rate and annual incidence rate in BRCA1 PSV carriers (n = 463) age 60–80 years followed up for an average of 7/9 years were 20.1% and 1.8% and for BRCA2 PSV carriers (n = 236) these rates were 17.3% and 1.7%, respectively.