Clonality analysis based on scTCR data supported this finding by demonstrating that the expansion of PD1+ TIM3+ Ttox EM3 cells was a key feature of the tumour microenvironment of DLBCL, FL and MZL, while MCL and tumour-free LNs were predominantly characterized by clonal PD1− Ttox EM1 cells (Fig. 4a). This evidence concerns the gene HAVCR2 and mantle cell lymphoma.