However, subsequent injection of lentiviral vector for RAD21 overexpression and YS-49 increased the size and weight of tumors developed from NIPBL-KD H1299 (Supplementary Fig. 9a, b) or H1650 cells (Supplementary Fig. 9c, d), demonstrating that RAD21 overexpression and YS-49 neutralized the inhibitory effect of NIPBL knockdown on NSCLC development in vivo. Here, RAD21 is linked to non-small cell lung carcinoma.