In contrast, abnormalities in total IgE concentration (5.9% [85/185] vs. 66.2% [1158/1751], p < 0.001) and eosinophil counts (7.5% [245/3256] vs. 15.6% [835/5365], p < 0.001) were significantly less frequent in the psoriasis group compared with the AD group. Here, IGHE is linked to Alzheimer disease.