CD40 and neoplasm: Inflammation pathways were generally upregulated, including tumor microenvironment pathway (z-score: 2.858, Up: 83/181, Down: 49/181); interleukin-10 signaling (z-score: 3.162, Up: 24/45, Down: 3/45); pathogen induced cytokine storm signaling pathway (Fig. 5; z-score: 2.268, Up: 127/370, Down: 79/370); and CD40 signaling (z-score: 0.707, Up: 38/69, Down: 25/69).