PTK2 and neoplasm: Our data may also indicates active tumor mechanotransduction, which is the ability of tumor cells to respond to mechanical external stimuli by activating intracellular signaling pathways, as observed by upregulated ECM protein encoding genes, cell adhesion and motility signatures coupled with upregulation of signaling pathways involved in cell adhesion (i.e, PTK2) and pathways influencing proliferation and survival (i.e., RTK).