In GBM, RORα reduced tumour-promoting inflammation by downregulation of the JAK2 (Janus Kinase 2)/STAT3 (Signal Transducer And Activator Of Transcription 3) /IL-6 (Interleukin 6) and the TNF-α/NF-κB pathway25,27. The gene discussed is STAT3; the disease is neoplasm.