The expression of BMAL1 was shown to be positively correlated with the pro-angiogenic factors HIF1α (Hypoxia Induced Factor 1 alpha), VEGF (Vascular Endothelial Growth Factor), and ANG2 (Angiopoietin 2) in a cohort of 79 patients of high- and low-grade glioma (HGG and LGG). This evidence concerns the gene ANGPT2 and glioma.