TIAM1 and glioblastoma: In GBM, both EMT68 and the levels of the RAC-GEF (Ras-Related C3 Botulinum Toxin Substrate 1 Guanine Exchange Factor) TIAM1 (T Cell Lymphoma Invasion And Metastasis 1), but not the levels of RAC1, were found to be rhythmic69 indicating an interplay between circadian rhythm and GBM motility.