Through its proprietary scoring method74, the IO360TM platform also revealed that GDC-0339, in combination with an anti-PD-1 or -PD-L1 antibody, moderately increased the abundance of tumor-infiltrating total and non-exhausted CD8 + T cells, resulting in a significantly higher “cytotoxic cells score” (Fig. 4h). Here, CD274 is linked to neoplasm.