Recently, the value of tumor marker index (TMI) consisting of cytokeratin 19 fragment (CYFRA21-1) and squamous cell carcinoma-related antigen (SCC-Ag) as a prognostic factor in squamous esophageal cancer or CYFRA21-1 and CEA as a prognostic factor in non-small cell lung cancer has been reported9,10. The gene discussed is CEACAM5; the disease is neoplasm.