Elevated protein levels of the ISG myxovirus resistance protein A (MxA) were detected in morphea lesions of a patient with DM2 (Fig. 1d, Supplementary Fig. 1a) as well as other lesional and non-lesional skin biopsies from DM2 patients (Fig. 1e). This evidence concerns the gene MX1 and myotonic dystrophy type 2.