In enterocytes, the recycling endosome proteins RAB8 and RAB11 are necessary for the localization of apical peptidases, transporters and toll-like receptors (TLR), where loss results in intracellular vacuoles, mislocalised proteins, and for Rab11a, spontaneous enteritis resembling our Becn1-deficient mice phenotype37,38. This evidence concerns the gene RAB8A and enteritis.