CATSPER2 and hearing loss disorder: The two different CNVs that were found in the solved cases were in the region 15q.15.3 and were classified as pathogenic, one of them was found in the patient as a homozygous gain of 71 kb that falls within the genes DFNB16 (STRC), CATSPER2, and CKMT1A. The other CNV was a deletion of 51 kb that falls within the genes DFNB16 (STRC) and CATSPER2. This region was reported in DECIPHER database in multiple cases with hearing loss (Table 4).