Based on previous findings indicating the expression of PSMA in tumor-associated endothelial cells in TNBC [11–13] and in the tumor vasculature of TNBC patient samples [10], we analyzed the therapeutic efficacy of [177Lu]Lu-PSMA-I&T endogenous radiotherapy in orthotopic TNBC xenografts in a single and a fractionated dose approach. The gene discussed is FOLH1; the disease is neoplasm.