TNFSF11 and Fabry disease: Recent work in murine models also supports the notion that RANKL inhibition enhances lesional mineralization and limits its expansion, in part through attenuation of osteoclast resorption.6,7 Understanding the effects of RANKL inhibition on FD cellular behavior and lesion composition therefore has the potential to inform understanding of FD and its management and the interplay between osteoclastic and osteoblastic lineages in health and disease.