CD8+ CD103+ cells were generated from naïve CD8+ T cells cultured with TGF-β in vitro and showed inhibition in vivo, as well as in an aggressive tumor model, and expressed Foxp3 [82–84]; CD8+ CD28− T cells were found in age-dependent accumulation and chronic antigen exposure [85–87]. The gene discussed is CD8A; the disease is neoplasm.