Herein, we investigate CD8+ T cells in MG, focusing on their potential effector and regulatory roles, as well as on evidence (peripheral, in situ, cerebrospinal fluid (CSF), and under different treatments), T-cell receptors (TCR) usage, cytokine and chemokine expression, cell marker expression, regulatory T cells, and Tc17 cells. The gene discussed is CD8A; the disease is myasthenia gravis.