The populations of CD8+CD28− and CD8+CD122+ Tregs did not differ between patients with MG and healthy controls; patients with MG exhibited a decrease in CD4+CD25highFoxp3+ Tregs and an increase in CD19+BAFF-R+ B cells, revealing that patients with MG should display the dysfunction of T-cell balance and the activation of B-cell maturation [106]. This evidence concerns the gene CD4 and myasthenia gravis.