Major histocompatibility complex (MHC) class I-restricted CD8+ T cells act as both effectors and/or regulators in various autoimmune diseases, such as multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE) [31–33], and animal models of uveitis—experimental autoimmune uveitis (EAU) [34]. This evidence concerns the gene CD8A and autoimmune disease.