Sig-1R is detected in various cells in the central nervous system (CNS) and has been implicated in several neurological disorders, including TBI [82–85], Alzheimer’s disease (AD) [86], Huntington’s disease (HD) [87], Parkinson’s disease (PD) [88], and amyotrophic lateral sclerosis (ALS) [89]. Here, SIGMAR1 is linked to Alzheimer disease.