By blocking these pro-inflammatory signaling pathways and attenuating cytokines including TNF-α, IL-1β, and IL-6, HIF-CaP-rHDL showed promise as a targeted remedy for RA.562 Persistent neurological inflammation caused by microglia is assumed to start in the early stages of AD and is essential to the etiology of the disease. The gene discussed is TNF; the disease is rheumatoid arthritis.