However, this changed when the orthogonality score was factored, with 10uM genistein (\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$Final Score= 1.38$$\end{document}FinalScore=1.38) being prioritized (Fig. 4B) as the most effective plant polyphenol in targeting and reversing the effects of breast cancer on the MEK5/ERK5 target protein subnetwork. This evidence concerns the gene MAP2K5 and breast carcinoma.