AGER and chronic obstructive pulmonary disease: Due to the lack of studies on miRNA regulation of RAGE in COPD, we screened bulk RNAseq data from COPD patients and healthy volunteers and found that miR-23a-5p is down-regulated, while RAGE is aberrantly upregulated, in COPD, which led to our hypothesis that RAGE may be a regulatory target of miR-23a-5p.