AGT and COVID-19: In addition, enhanced levels of vasoactive compounds, such as angiotensin II (Ang II) or thromboxane A2 (TXA2), which are potent vasoconstrictors and effectors of endothelial dysfunction with pro-inflammatory, pro-adhesive and pro-coagulant properties can play a role in the endotheliopathy associated to COVID-19 [32, 33] (Fig. 2).