Although acute liver injury has also been reported in COVID-19 cases due to inflammation, cytokine storm, hypoxia, hypoperfusion, and direct cytopathic effect [29], there has been no significant statistical relation between ALT and AST levels as liver function enzymes and any other inflammatory biomarker measured in our study which in turn supports the hypoxia and direct cytopathic effect due to viral tropism to angiotensin-converting enzyme 2 (ACE2) receptors in liver cells as the probable causes of acute liver impairment. This evidence concerns the gene GPT and COVID-19.