In addition to our previously discovered EGFR-driven EMT in HNSCC [22], the observations presented here add another facet to the repertoire of HNSCC cell responses to FGFR targeting and irradiation: an EGFR-driven pEMT phenotype is activated in FGFR-inhibited HNSCC cells. The gene discussed is EGFR; the disease is head and neck squamous cell carcinoma.