EGFR and head and neck squamous cell carcinoma: A more in-depth computational functional characterization through a correlation of expression profiles of our 20 signature genes with inferred signaling pathway activities using PROGENy (Pathway RespOnsive GENes for activity inference) revealed the strongest positive correlation for EGFR and MAPK activity in both bulk and scRNA-Seq from HNSCC patient samples (Fig. 7D).