APOE and dementia: The HR (95% CI) for dementia associated with C-reactive protein (quintile 1 versus quintile 5) was 1.02 (0.88–1.18) in non-APOE4 carriers and 1.39 (1.23–1.57) in APOE4 carriers (P-value for interaction = 0.0001, Fig. 4).