Lower C-reactive protein was associated with a higher risk of incident AD in APOE4 carriers (HR (95% CI) for quintile 1 versus quintile 5: 1.52(1.28–1.81)) but not in non-APOE4 carriers (1.16 (0.91–1.47), P-value for interaction = 0.0071, Fig. 5). The gene discussed is APOE; the disease is Alzheimer disease.