In non-APOE4 carriers, the leading risk factors for all-cause dementia included high multimorbidity risk score (PAR (95% CI): 47.1% (37.3–55.6%)), low overall self-rated health (40.3% (23.9–43.0%)), low household income (37.6% (18.5–53.9%)), long-term illness (25.8% (22.6–29.3%)), high microalbumin in urine (19.5% (9.1–28.9%)), high neutrophil count (18.6% (10.1–26.7%)), low greenspace percentage (17.0% (6.7–26.6%)), and high creatinine in urine (17.0% (6.9–26.3%)). The gene discussed is APOE; the disease is dementia.