In conclusion, CT infection exacerbates the activation of the PI3K/Akt pathway and the suppression of the MARK pathways during HPV infection, downregulates surface activation marker expression and decreases LC numbers,impairs the immune cytotoxicity of CD4+ and CD8+ T cells, and inhibits cell-mediated immunity and HPV clearance; these phenomena enhance persistent HPV infection, accelerate the natural process of HPV infection and lead to the development of precancerous lesions and cervical cancer. Here, CD8A is linked to cervical cancer.