AKT1 and cervical cancer: The primary objective of this study was to investigate whether CT exacerbates HPV-induced immune suppression by dysregulating the PI3K/AKT and MAPK pathways and inhibiting the antigen-presenting abilities of LCs and to determine whether CT infection can change T-cell subsets and induce apoptosis, thus to define the immune mechanism of CT in enhancing persistent HPV infection and accelerating the progression of cervical cancer.