In conclusion, CT infection exacerbates the activation of the PI3K/Akt pathway and the suppression of the MARK pathways during HPV infection, downregulates surface activation marker expression and decreases LC numbers,impairs the immune cytotoxicity of CD4+ and CD8+ T cells, and inhibits cell-mediated immunity and HPV clearance; these phenomena enhance persistent HPV infection, accelerate the natural process of HPV infection and lead to the development of precancerous lesions and cervical cancer. The gene discussed is MARK1; the disease is cervical cancer.