Gastric cancer is an epidemic malignancy, which is always diagnosed at the late stage.3 Thus, despite the advance and survival of gastric cancer have been prominently increased in recent decades, the prognosis remains discontented duo to its high recurrence rate.16 Evidence has elaborated that RAD54B exerts a significant role in a variety of cancers17, but its specific role and mechanism in gastric cancer are still unknown. The gene discussed is RAD54B; the disease is gastric cancer.