High expression of RAD54B has been founded in a series of cancers, such as breast cancer and its subtype9,18, HCC10,19, lung cancer11, and colorectal cancer12, which has been verified in our pan-cancer analysis, as indicated by a remarkable increase of RAD54B expression in BRCA, LIHC, LUAD, LUSC, COAD and READ. The gene discussed is RAD54B; the disease is breast cancer.