Besides, the latest WHO CNS classification emphasizes the role of molecular markers, such as IDH, 1p19q, CDKN2A/B, 7+/10−, and EGFR, in the diagnosis and prediction of the prognosis of gliomas.4 From this prospect, Imnecrosis might be more critical than Panecrosis since it can be non-invasively obtained before operation. This evidence concerns the gene IDH2 and central nervous system cancer.