Additionally, cell migration and invasion assays revealed that down-regulation of METTL17 in RKO, SW620, and DLD1 cells dramatically suppressed their ability to migrate across membranes and invade through matrix-coated membranes (Fig. 2G and Supplementary Fig. 3A), indicating that METTL17 knockdown impedes the migration and invasion of CRC cells. This evidence concerns the gene METTL17 and colorectal carcinoma.