Consistent with the observed correlations in the CTRP, DepMap, and CCLE datasets, knockdown of METTL17 in SW620 and RKO, two colorectal cancer cells expressing high levels of METTL17 (Fig. 2D), increased sensitivity to ML162 or RSL3-induced ferroptosis, while the cell viability was rescued by the iron chelator deferoxamine (DFO) (Fig. 1D and E). Here, METTL17 is linked to colorectal cancer.