Additionally, propidium iodide (PI) staining revealed that ML162 or RSL3 treated METTL17-deficient cells exhibited more cell deaths, which were significantly reversed by DFO (Fig. 1F, G, H and Supplementary Fig. 1A, B, C), suggesting that knockdown of METTL17 sensitized CRC cells to GPX4 inhibition. Here, GPX4 is linked to colorectal carcinoma.