Karimi Galougahi et al. found that hyperglycemia induced by continuous subcutaneous infusion of the insulin receptor antagonist S961 in male New Zealand white rabbits reduced this co-immunoprecipitation of Grx1 and β1 subunits in cardiomyocytes and increased the Na+/K+ pump β1 subunit glutathionylation, inhibiting the ion flux. The gene discussed is GLRX; the disease is Hyperglycemia.