Infectivity tests showed that rI-NPF450L exhibited a 104−6-fold enhancement in TCID50 value compared to the rI4 strain (Fig 3J), while rH-NPL450F, rK-NPL450F, and rL-NPR450F showed approximately a 104−6-fold reduction in TCID50 value relative to rHerts/33, rKuwait, and rLa Sota (Fig 3K–3M) on four tumor cell lines. The gene discussed is RELN; the disease is neoplasm.