DNM1L and Alzheimer disease: Some mechanistic studies performed by Zhang and collaborators have indicated that, in mature OLs of AD mice, an abnormally hyperactivated mitochondrial fission enzyme dynamin-related protein 1 (Drp1) inhibits hexokinase-1, a mitochondrial enzyme that initiates glycolysis, resulting in an energy deficiency and the impairment of energy-consuming myelination processes [59].