ATM and pancreatic neoplasm: Therefore, to test the antitumor efficacy of ATM inhibitor and radiotherapy, as well as their ability to sensitize to anti–PD-L1 immune checkpoint blockade, we established mT4 pancreatic tumors in syngeneic C57BL/6 mice that were subsequently treated with AZD1390, radiation, and/or anti–PD-L1 as illustrated (Figure 3A).