Although our prior study (12) suggested that radiation and the DNA-dependent protein kinase (DNA-PK) inhibitor peposertib (M3814) promote T1IFN induction via a POLIII/RIG-I/MAVS-dependent manner, it is unknown whether this is a common pathway connecting the radiation-induced cytosolic nucleic acids and T1IFN in pancreatic cancer cells. Here, PRKDC is linked to familial pancreatic carcinoma.