Her positive history for lupus antibodies and factor V Leiden mutation, and increased levels of CRP and ANA suggest an association with the antiphospholipid syndrome and an overall prothrombogenic situation that may have caused renal vein thrombosis subsequently leading to acute kidney injury and hyperkalemia secondary to primary hypoaldosteronism due to thrombosis of the adrenal vein. The gene discussed is F5; the disease is acute kidney injury.