With the aid of a KM plotter, we discovered that patients with HNSCC had a dismal prognosis when DKK1 expression was higher in macrophages (p = 1.7e−05), mesenchymal stem cells (p = 0.001), NK T cells (p = 0.011), Th1 cells (p = 3.3e−05), Th2 cells (p = 7.6e−08), Treg cells (p = 1.5e−05), CD8+ T cells (1.6e−06), CD4+ memory T cells (p = 2e−08), and B cells (p = 2.7e−06) (Figure 6A–6I). The gene discussed is CD8A; the disease is head and neck squamous cell carcinoma.