FH and familial hyperaldosteronism: FH-dRCC has a younger age of onset and more rapid disease progression, and immunohistochemistry of FH and 2-SC can distinguish well between the two, considering that not all cases of FH-dRCC cases show FH staining deficiency and diffuse 2-SC staining in immunohistochemical assays, FH gene mutation analysis should still be considered in patients with suspicious clinical or pathological features.