The inflammatory response plays an important role in the process of atherosclerosis, and the risk of plaque rupture is increased by accelerated macrophage infiltration in the presence of arterial injury, while TNF‐α is an important cytokine in the inflammatory response, so TNF‐α plays an important role in the development of atherosclerosis (Sengeløv et al., 2018; T. Wang & He, 2020). This evidence concerns the gene TNF and atherosclerosis.