The results of logistic regression model showed that the increase of Lp(a), TG/HDL‐C, HBA1C, Lp‐PLA2, CRP, CysC, Hcy, and NLR could increase the risk of carotid artery unstable plaque in patients with ischemic stroke (p < .05). Here, PLA2G7 is linked to ischemic stroke.