In this study, the comparison of routine blood, blood glucose, blood pressure, and inflammatory indexes between groups A and B revealed that the values of HBA1C, Lp‐PLA2, CRP, CysC, Hcy, TNF‐α, N, and NLR were higher in group B than in group A. These factors have been found to be the risk of unstable carotid plaque in patients with ischemic stroke. This evidence concerns the gene TNF and ischemic stroke.