Brain ischemic injury caused by stroke leads to systemic inflammatory responses and the production of various inflammatory mediators such as TNF‐α, IL‐6, and IL‐1β (Daidone et al., 2021; Tuttolomondo et al., 2016), which are also involved in the neuroinflammatory mechanisms of PSD (Wei et al., 2021). This evidence concerns the gene TNF and stroke disorder.