This phenomenon may be explained by the fact that older women have significantly higher levels of follicle‐stimulating hormone (FSH) than older men, and that the increased FSH binds to the FSH receptor on the surface of neurons and activates the C/EBPβ/AEP pathway, which in turn triggers an increase in Aβ and Tau pathology, leading to a greater risk of cognitive impairment in women (Xiong et al., 2022). This evidence concerns the gene LGMN and Cognitive impairment.