Coant N et al. demonstrated that the AKT signaling pathway could accelerate cell cycle progression and cell proliferation in CRC in vitro and vivo.14 Hai Huang et al. discovered that cell cycle arrest at the G2/M phase can be regulated by the suppression of AKT phosphorylation in vitro.47 In our study, we observed that CCND1 played a key role in the promotion of cell cycle progression by MDFI. Here, MDFI is linked to colorectal carcinoma.