Among these modules, the gray module was strongly correlated with most of the PI3K-AKT signaling pathway-associated genes (COL1A1, ITGB4, COL1A2, COL6A1, DDIT4, SPP1, LAMB3, ITGA3, EPHA2 and ITGB1) and tumor stage (Figure S2D). Here, SPP1 is linked to neoplasm.