TYMS and colorectal carcinoma: Oxaliplatin and 5-fluorouracil (5-FU) are important components of systemic chemotherapy for CRC, and antitumor efficacy is mainly achieved by inhibiting thymidylate synthase to disrupt DNA replication and inhibit DNA damage repair.24,25 With the development of drug resistance in CRC, it is difficult to obtain continuous antitumor effects of chemotherapy drugs and overcome clinical drug resistance.