Available studies indicate that the MDFI is a novel biomarker for poor prognosis in tumors, including colorectal, brain, gastric lung and pancreatic tumors.10,39–41 Chen Mi and Sui Y et al. discovered that inhibition of MDFI attenuates proliferation in both studies.10,42 However, the direct regulatory mechanism of MDFI in tumors has not been elucidated. Here, MDFI is linked to pancreatic neoplasm.