,S38 The expression of IL‐4 and IL‐13 in skeletal muscle is elevated after strength training.S38 IL‐4 administration to C26 colon carcinoma‐bearing mice rescues muscle mass, which is associated with the reestablished number and function of SCs.S39 IL‐4 has been demonstrated to directly stimulate myocyte differentiation of C2C12 cells (a mouse myoblast cell line).S39 Muscle cells are the dominant source of IL‐6, and exercise can induce a 100‐fold increase in the plasma of IL‐6 concentration; this increase is attributed to cytoplasmic Ca2+ and ionic enzymes in exercised skeletal muscle.10, 69. This evidence concerns the gene IL6 and colon carcinoma.