Female gender was more frequent, and smoking,obesity, and anemia were reported in a proportion of subjects (Table 1).However, a comparison of the baseline data showed no significant difference between the two study groups in terms of mean age, gender distribution, smoking status, mean body mass index (BMI),duration of asthma, FeNO, and mean values of blood IgE, IgG, hemoglobin, eosinophil, and total white blood cell count (Table 1). The gene discussed is IGHE; the disease is obesity due to melanocortin 4 receptor deficiency.