YWHAQ and Creutzfeldt Jacob disease: 14-3-3 proteins are detectable in cerebrospinal fluid in different neurodegenerative conditions like multiple sclerosis (Colucci et al., 2004), Creutzfeldt-Jakob disease (Hsich et al., 1996; Shiga et al., 2006), and HIV-associated neurodegeneration (Morales et al., 2012).