- Netrin-1 and Netrin-4 delay the growth of lung, pancreatic and prostate tumors.- Netrin-1 promotes the growth of glioma cells by activating NF-κB signaling via UNC5A.- Netrin-1 is a positive regulator of malignant tumor metastasis by activating YAP signaling.- Netrin-1 induces antiapoptotic effects of acute myeloid leukemia cells through Unc5B.- Loss of netrin-1 receptor DCC is associated with a poor prognosis in patients with colorectal tumors, glioblastoma, and breast carcinoma.- Netrin-1 stimulates tumor progression in breast, cancer and medulloblastoma. Here, UNC5B is linked to central nervous system cancer.