IRF1 and neoplasm: In ICR gene clusters (Figure 3A), the results showed strong correlations between the density of T cell subtypes and the expression of genes, such as IFNG, IRF1, and STAT1. These genes play pivotal roles in the tumor immune response, particularly in T cell activation, cytokine production, and anti-tumor immune response, suggesting that the ICR captures a higher T cell infiltrated TME.