This spatial separation could potentially reduce the inhibitory effects of CD3+FoxP3+ T cells on the antitumor activities of CD3+CD8-FoxP3- and CD3+CD8+ T cells, resulting in a more potent immune response against the tumor and thereby reinforcing the notion that higher ICR immune subtypes are associated with a more robust antitumor immune response (18, 20). The gene discussed is CD8A; the disease is neoplasm.